GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs3796352 | 1 | rs3796352 | chr3:52913279 | TMEM110 | chr3:52867139-52931547:- | 0.47 | 4.35 | 1.76E-5 | Immune reponse to smallpox (secreted IL-2) |
| BLCA | cis | rs2130392 | 1 | rs3796689 | chr4:185649866 | MLF1IP | chr4:185615220-185655286:- | -0.47 | -11.04 | 9.0E-25 | Kawasaki disease |
| BLCA | cis | rs9473555 | 1 | rs3806988 | chr6:49431569 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.41 | 1.11E-7 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs3806988 | chr6:49431569 | MUT | chr6:49398994-49431031:- | 0.29 | 5.66 | 2.95E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs8072100 | 1 | rs3809868 | chr17:45750596 | C17orf57 | chr17:45401142-45518675:+ | -0.26 | -5.75 | 1.79E-8 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BLCA | cis | rs4803468 | 1 | rs3810174 | chr19:41904165 | B3GNT8 | chr19:41931265-41934635:- | -0.2 | -3.84 | 0.000144 | Height |
| BLCA | cis | rs4803468 | 1 | rs3810175 | chr19:41904396 | B3GNT8 | chr19:41931265-41934635:- | 0.21 | 3.87 | 0.000127 | Height |
| BLCA | cis | rs12220238 | 1 | rs3812638 | chr10:75896072 | ADK | chr10:75910965-76469059:+ | 0.33 | 4.82 | 2.04E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs3812638 | chr10:75896072 | AP3M1 | chr10:75880016-75910826:- | 0.32 | 4.06 | 5.83E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs9309473 | 1 | rs3813227 | chr2:73651967 | ALMS1P | chr2:73872046-73912692:+ | -0.37 | -5.45 | 8.95E-8 | Metabolite levels |
| BLCA | cis | rs9473555 | 1 | rs3823114 | chr6:49431720 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.65 | 3.17E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs3823114 | chr6:49431720 | MUT | chr6:49398994-49431031:- | 0.28 | 5.51 | 6.48E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs703842 | 1 | rs3825079 | chr12:58203354 | FAM119B | chr12:58166383-58176323:+ | 0.28 | 4.45 | 1.12E-5 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs3825079 | chr12:58203354 | TSFM | chr12:58176536-58191367:+ | -0.39 | -6.89 | 2.36E-11 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs3825079 | chr12:58203354 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.24 | -4.12 | 4.66E-5 | Multiple sclerosis |